基于matlab对比度和结构提取的多模态解剖图像融合实现

一、简介

应用多模态图像的配准与融合技术,可以把不同状态的医学图像有机地结合起来,为临床诊断和治疗提供更丰富的信息。介绍了多模态医学图像配准与融合的概念、方法及意义。最后简单介绍了小波变换分析方法。

二、部分源代码

clear; close all; clc; warning off
%% A Novel Multi-Modality Anatomical Image FusionMethod Based on Contrast and Structure Extraction
% F = fuseImage(I,scale)

%Inputs:
%I - a mulyi-modal anatomical image sequence

%scale - scale factor of dense SIFT, the default value is 16

%% load images from the folder that contain multi-modal image to be fused
%I=load_images('./Dataset\CT-MRI\Pair 1');
I=load_images('./Dataset\MR-T1-MR-T2\Pair 1');
%I=load_images('./Dataset\MR-Gad-MR-T1\Pair 1');
% Show source input images 
figure;
no_of_images = size(I,4);
for i = 1:no_of_images
  subplot(2,1,i); imshow(I(:,:,:,i));
end
suptitle('Source Images');


%%
F=fuseImage(I,16);
%% Output: F - the fused image

F=rgb2gray(F);
figure;
imshow(F);
function [ F ] = fuseImage(I,scale)


addpath('Pyramid_Decomposition');
addpath('Guided_Filter');
addpath('Dense_SIFT');

tic
%%
[H, W, C, N]=size(I);
imgs=im2double(I);
IA=zeros(H,W,C,N);
for i=1:N
IA(:,:,:,i)=enhnc(imgs(:,:,:,i));

end
%%
imgs_gray=zeros(H,W,N);
for i=1:N
  imgs_gray(:,:,i)=rgb2gray(IA(:,:,:,i));
end
%
% %dense sift calculation
dsifts=zeros(H,W,32,N, 'single');
for i=1:N
  img=imgs_gray(:,:,i);
  ext_img=img_extend(img,scale/2-1);
  [dsifts(:,:,:,i)] = DenseSIFT(ext_img, scale, 1);
  
end
%%
%local contrast
contrast_map=zeros(H,W,N);
for i=1:N
  contrast_map(:,:,i)=sum(dsifts(:,:,:,i),3);

end


%winner-take-all weighted average strategy for local contrast

[x, labels]=max(contrast_map,[],3);
clear x;
for i=1:N
  mono=zeros(H,W);
  mono(labels==i)=1;
  contrast_map(:,:,i)=mono;

end



%% Structure 
h = [1 -1];
structure_map=zeros(H,W,N);

for i=1:N
structure_map(:,:,i) = abs(conv2(imgs_gray(:,:,i),h,'same')) + abs(conv2(imgs_gray(:,:,i),h','same')); %EQ 13

 
end


%winner-take-all weighted average strategy for structure

[a, label]=max(structure_map,[],3);
clear x;
for i=1:N
  monoo=zeros(H,W);
  monoo(label==i)=1;
  structure_map(:,:,i)=monoo;
   
end

%%
weight_map=structure_map.*contrast_map;




%weight map refinement using Guided Filter
for i=1:N
  
  weight_map(:,:,i) = fastGF(weight_map(:,:,i),12,0.25,2.5);

end



% normalizing weight maps
%
weight_map = weight_map + 10^-25; %avoids division by zero
weight_map = weight_map./repmat(sum(weight_map,3),[1 1 N]);

%% Pyramid Decomposition

% create empty pyramid
pyr = gaussian_pyramid(zeros(H,W,3));
nlev = length(pyr);

% multiresolution blending
for i = 1:N
  % construct pyramid from each input image
 
  % blend
  for b = 1:nlev
      w = repmat(pyrW{b},[1 1 3]);
      
      pyr{b} = pyr{b} + w .*pyrI{b};
  end
  
end

% reconstruct
F = reconstruct_laplacian_pyramid(pyr);

toc

end